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Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM145767
Substrate
n/a
Meas. Tech.
FLAP Binding Assay
Ki
150±n/a nM
Citation
 Chai, W; Dvorak, CA; Eccles, W; Edwards, JP; Goldberg, SD; Krawczuk, PJ; Lebsack, AD; Liu, J; Pippel, DJ; Sales, ZS; Tanis, VM; Tichenor, MS; Wiener, JJ 1,2,6-substituted benzimidazoles as flap modulators US Patent  US9695149 Publication Date 7/4/2017 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM145767
Synonyms:
US8952177, 121 | US9089569, 121 | US9695149, 121
Type:
Small organic molecule
Emp. Form.:
C28H29N3O3
Mol. Mass.:
455.5482
SMILES:
Cc1ccc(Cn2c(nc3ccc(OCc4ccc(C)cn4)cc23)[C@@H]2[C@H](C(O)=O)C2(C)C)cc1 |r|
Structure:
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