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Target
Wee1-like protein kinase
Ligand
BDBM264269
Substrate
n/a
Meas. Tech.
Wee-1 kinase Assay
Temperature
298.15±n/a K
IC50
<10±n/a nM
Comments
extracted
Citation
 O Dowd, CR; Rountree, JS; Burkamp, F; Wilkinson, AJ Substituted pyrido[4,3-d]pyrimidines as Wee-1 inhibitors US Patent  US9714244 Publication Date 7/25/2017 
Target
Name:
Wee1-like protein kinase
Synonyms:
Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN
Type:
PROTEIN
Mol. Mass.:
71599.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1445054
Residue:
646
Sequence:
MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDSPLPPARSPTEPGPERRRSPGPAPGSPGELEEDLLLPGACPGADEAGGGAEGDSWEEEGFGSSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFRKLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTPDSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKKAQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY
  
Inhibitor
Name:
BDBM264269
Synonyms:
6-(2,6-Dichlorophenyl)-2-((4-(piperazin-1-yl)phenyl)amino)-8-(pyridin-3-yl)pyrido[4,3-d]pyrimidin-5(6H)-one | US9714244, 23
Type:
Small organic molecule
Emp. Form.:
C28H23Cl2N7O
Mol. Mass.:
544.435
SMILES:
Clc1cccc(Cl)c1-n1cc(-c2cccnc2)c2nc(Nc3ccc(cc3)N3CCNCC3)ncc2c1=O |(5.33,5,;6.67,4.23,;8,5,;9.34,4.23,;9.34,2.69,;8,1.93,;8,.38,;6.67,2.69,;5.33,1.93,;5.33,.38,;4,-.38,;4,-1.93,;2.67,-2.69,;2.67,-4.23,;4,-5,;5.33,-4.23,;5.33,-2.69,;2.67,.38,;1.33,-.38,;,.38,;-1.33,-.38,;-2.67,.38,;-4,-.38,;-5.33,.38,;-5.33,1.93,;-4,2.69,;-2.67,1.93,;-6.67,2.69,;-8,1.93,;-9.34,2.69,;-9.34,4.23,;-8,5,;-6.67,4.23,;,1.93,;1.33,2.69,;2.67,1.93,;4,2.69,;4,4.23,)|
Structure:
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