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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM264372
Substrate
n/a
Meas. Tech.
Kinase Assays
IC50
<100.0±n/a nM
Citation
 Zeng, Q; Faris, M; Mollard, A; Warner, SL; Flynn, GA Multiple kinase pathway inhibitors US Patent  US9714247 Publication Date 7/25/2017 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM264372
Synonyms:
US9714247, 93
Type:
Small organic molecule
Emp. Form.:
C28H30F2N6O2
Mol. Mass.:
520.5736
SMILES:
CCn1c2cc(Nc3ccc(OCCN4CCN(C)CC4)cn3)ncc2cc(-c2c(F)cccc2F)c1=O |(4.67,-3.85,;6,-3.08,;6,-1.54,;4.67,-.77,;3.33,-1.54,;2,-.77,;.67,-1.54,;-.67,-.77,;-.67,.77,;-2,1.54,;-3.33,.77,;-4.67,1.54,;-6,.77,;-6,-.77,;-7.34,-1.54,;-8.67,-.77,;-10,-1.54,;-10,-3.08,;-11.34,-3.85,;-8.67,-3.85,;-7.34,-3.08,;-3.33,-.77,;-2,-1.54,;2,.77,;3.33,1.54,;4.67,.77,;6,1.54,;7.34,.77,;8.67,1.54,;8.67,3.08,;7.34,3.85,;10,3.85,;11.34,3.08,;11.34,1.54,;10,.77,;10,-.77,;7.34,-.77,;8.67,-1.54,)|
Structure:
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