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Target
Tyrosine-protein kinase Lyn
Ligand
BDBM264419
Substrate
n/a
Meas. Tech.
Kinase Assays
IC50
<100.0±n/a nM
Citation
 Zeng, Q; Faris, M; Mollard, A; Warner, SL; Flynn, GA Multiple kinase pathway inhibitors US Patent  US9714247 Publication Date 7/25/2017 
Target
Name:
Tyrosine-protein kinase Lyn
Synonyms:
JTK8 | LYN | LYN_HUMAN | Lck/Yes-related novel protein tyrosine kinase | Tyrosine-protein kinase Lyn (LYN) | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog | p53Lyn | p56Lyn
Type:
Protein
Mol. Mass.:
58575.92
Organism:
Homo sapiens (Human)
Description:
P07948
Residue:
512
Sequence:
MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
  
Inhibitor
Name:
BDBM264419
Synonyms:
US9714247, 141 | US9714247, 142
Type:
Small organic molecule
Emp. Form.:
C23H17F3N4O2
Mol. Mass.:
438.4019
SMILES:
Fc1ccc(Nc2cc3n(C4CCOC4)c(=O)c(cc3cn2)-c2c(F)cccc2F)nc1 |(-4.67,-5.78,;-4.67,-4.23,;-3.33,-3.47,;-3.33,-1.93,;-4.67,-1.15,;-4.67,.38,;-3.33,1.15,;-2,.38,;-.67,1.15,;.67,.38,;.67,-1.15,;-.58,-2.06,;-.1,-3.52,;1.44,-3.52,;1.91,-2.06,;2,1.15,;3.33,.38,;2,2.69,;.67,3.47,;-.67,2.69,;-2,3.47,;-3.33,2.69,;3.33,3.47,;3.33,5,;2,5.78,;4.67,5.78,;6,5,;6,3.47,;4.67,2.69,;4.67,1.15,;-6,-1.93,;-6,-3.47,)|
Structure:
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