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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM264423
Substrate
n/a
Meas. Tech.
Kinase Assays
IC50
<100.0±n/a nM
Citation
 Zeng, Q; Faris, M; Mollard, A; Warner, SL; Flynn, GA Multiple kinase pathway inhibitors US Patent  US9714247 Publication Date 7/25/2017 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM264423
Synonyms:
US9714247, 145 | US9714247, 146
Type:
Small organic molecule
Emp. Form.:
C29H31Cl2N5O3
Mol. Mass.:
568.494
SMILES:
CCN(CC)CCOc1ccc(Nc2cc3n(C4CCOC4)c(=O)c(cc3cn2)-c2c(Cl)cccc2Cl)nc1 |(-11.34,1.57,;-10,2.34,;-8.67,1.57,;-8.67,.03,;-10,-.74,;-7.34,2.34,;-6,1.57,;-4.67,2.34,;-3.33,1.57,;-3.33,.03,;-2,-.74,;-.67,.03,;.67,-.74,;2,.03,;3.33,-.74,;4.67,.03,;6,-.74,;6,-2.28,;4.76,-3.19,;5.23,-4.65,;6.77,-4.65,;7.25,-3.19,;7.34,.03,;8.67,-.74,;7.34,1.57,;6,2.34,;4.67,1.57,;3.33,2.34,;2,1.57,;8.67,2.34,;10,1.57,;10,.03,;11.34,2.34,;11.34,3.88,;10,4.65,;8.67,3.88,;7.34,4.65,;-.67,1.57,;-2,2.34,)|
Structure:
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