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TargetAldo-keto-reductase family 1 member C3
LigandBDBM264482
Substrate/Competitorn/a
Meas. Tech.AKR1C3-Inhibitory Action
pH7±n/a
IC50 34.0±n/a nM
Commentsextracted
Citation Bothe, UBusemann, MBarak, NRotgeri, AFischer, OMMarquardt, T Estra-1,3,5(10),16-tetraene-3-carboxamides for inhibition of 17.beta.-hydroxysteroid dehydrogenase (AKR1C3) US Patent US9714266 Publication Date 7/25/2017
More Info.:Get all data from this article,  Assay Method
 
Aldo-keto-reductase family 1 member C3
Name:Aldo-keto-reductase family 1 member C3
Synonyms:3-alpha-HSD type 2 | Aldo-keto reductase family 1 member C3 | Aldo-keto reductase family 1 member C3 (AK1C3) | Aldo-keto reductase family 1 member C3 (AK1C3a) | Aldo-keto reductase family 1 member C3 (AKR1C3) | Dihydrodiol dehydrogenase 3 | Dihydrodiol dehydrogenase type I | Estradiol 17-beta-dehydrogenase | Prostaglandin F synthase | Testosterone 17-beta-dehydrogenase 5 | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
Type:Enzyme
Mol. Mass.:36859.86
Organism:Homo sapiens (human)
Description:P42330
Residue:323
Sequence:
MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM
SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP
GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD
RNLHYFNSDSFASHPNYPYSDEY
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BDBM264482
NameBDBM264482
Synonyms:US9714266, 11 | methyl 11-fluoro-17-(5-fluoropyridin-3-yl)oestra-1,3,5(10),16-tetraene-3-carboxylate
TypeSmall organic molecule
Emp. Form.C25H25F2NO2
Mol. Mass.409.4683
SMILES[H][C@@]12CC=C(c3cncc(F)c3)[C@@]1(C)C[C@H](F)[C@]1([H])c3ccc(cc3CC[C@@]21[H])C(=O)OC |r,t:3|
Structure
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