Target
Cholesteryl ester transfer protein
Ligand
BDBM264520
Substrate
n/a
Meas. Tech.
Radioactive Assays of CETP-Catalyzed CE and TG Transfer (RTA Assay)
IC50
173±n/a nM
Citation
 Ondeyka, DQian, XVachal, PTyagarajan, SSmith, CJLi, HBao, J Spirocyclic CETP inhibitors US Patent  US9717714 Publication Date 8/1/2017 
Target
Name:
Cholesteryl ester transfer protein
Synonyms:
CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:
Enzyme
Mol. Mass.:
54751.53
Organism:
Homo sapiens (Human)
Description:
P11597
Residue:
493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
  
Inhibitor
Name:
BDBM264520
Synonyms:
4-[2'-({(7R)-7-[3,5- bis(trifluoromethyl)phenyl]- 5-oxo-6-oxa-4- azaspiro[2.4]hept-4- yl}methyl)-2-methoxy-6'- (trifluoromethyl)-3,3'- bipyridin-5-yl]-3- methylbenzoic acid | US9717714, 4
Type:
Small organic molecule
Emp. Form.:
C34H24F9N3O5
Mol. Mass.:
725.5571
SMILES:
COc1ncc(cc1-c1ccc(nc1CN1C(=O)O[C@H](c2cc(cc(c2)C(F)(F)F)C(F)(F)F)C11CC1)C(F)(F)F)-c1ccc(cc1C)C(O)=O |r|
Structure:
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