Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM37034
Substrate
n/a
Meas. Tech.
Dose Response Assays for S1P1 Agonists and Agonism Potentiators - Potentiator Assay 60K MLSMR
EC50
>10000±n/a nM
Citation
 PubChem, PC Dose Response Assays for S1P1 Agonists and Agonism Potentiators - Potentiator Assay 60K MLSMR PubChem Bioassay (2007)[AID] 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Homo sapiens (Human)
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM37034
Synonyms:
MLS000087191 | N-[1-(4-chlorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl]-5-(2,5-dimethoxyphenyl)isoxazole-3-carboxamide | N-[1-(4-chlorobenzyl)-3,5-dimethyl-pyrazol-4-yl]-5-(2,5-dimethoxyphenyl)isoxazole-3-carboxamide | N-[1-[(4-chlorophenyl)methyl]-3,5-dimethyl-4-pyrazolyl]-5-(2,5-dimethoxyphenyl)-3-isoxazolecarboxamide | N-[1-[(4-chlorophenyl)methyl]-3,5-dimethyl-pyrazol-4-yl]-5-(2,5-dimethoxyphenyl)-1,2-oxazole-3-carboxamide | N-[1-[(4-chlorophenyl)methyl]-3,5-dimethylpyrazol-4-yl]-5-(2,5-dimethoxyphenyl)-1,2-oxazole-3-carboxamide | SMR000023414 | cid_3236433
Type:
Small organic molecule
Emp. Form.:
C24H23ClN4O4
Mol. Mass.:
466.917
SMILES:
COc1ccc(OC)c(c1)-c1cc(no1)C(=O)Nc1c(C)nn(Cc2ccc(Cl)cc2)c1C
Structure:
Search PDB for entries with ligand similarity: