Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase B-raf [409-765]
Ligand
BDBM185584
Substrate
n/a
Meas. Tech.
RAF Kinase Activity
IC50
121±n/a nM
Citation
 Bae, IH; Son, JB; Han, SM; Kwak, EJ; Kim, HS; Song, JY; Byun, EY; Jun, SA; Ahn, YG; Suh, KH Thieno[3,2-D]pyrimidine derivatives having inhibitory activity for protein kinases US Patent  USRE47451 Publication Date 6/25/2019 
Target
Name:
Serine/threonine-protein kinase B-raf [409-765]
Synonyms:
B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1
Type:
COOH-terminal kinase domain
Mol. Mass.:
40238.92
Organism:
Homo sapiens (Human)
Description:
Recombinant baculoviruses expressing B-RAF (residues 409-765) was purified as a fusion protein.
Residue:
357
Sequence:
SLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPV
  
Inhibitor
Name:
BDBM185584
Synonyms:
US9156852, 1 | USRE47451, Example 1
Type:
Small organic molecule
Emp. Form.:
C23H17ClN6OS
Mol. Mass.:
460.939
SMILES:
Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1NC(=O)c1csc2c(N)ncnc12
Structure:
Search PDB for entries with ligand similarity: