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Target
Tumor necrosis factor
Ligand
BDBM403419
Substrate
n/a
Meas. Tech.
TNF or CD40L-Induced HEK-Blue Assay
IC50
17500±n/a nM
Citation
 Xiao, H; Dhar, TM; Jiang, B; Duan, J Cyclic compounds useful as modulators of TNF α US Patent  US10335392 Publication Date 7/2/2019 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM403419
Synonyms:
US10335392, Example 26 | rac-2-(5-((1aR,8S,8aS)-8-(2-(benzyloxy)phenyl)-4-fluoro-1,1a,8,8a-tetrahydrobenzo[d]cyclopropa[3,4]pyrrolo[1,2-a]imidazol-5-yl)pyrimidin-2-yl)propan-2-ol and rac-2-(5-((1aR,8R,8aS)-8-(2-(benzyloxy)phenyl)-4-fluoro-1,1a,8,8a-tetrahydrobenzo[d]cyclopropa[3,4]pyrrolo[1,2-a]imidazol-5-yl)pyrimidin-2-yl)propan-2-ol
Type:
Small organic molecule
Emp. Form.:
C31H27FN4O2
Mol. Mass.:
506.5701
SMILES:
CC(C)(O)c1ncc(cn1)-c1cc2n3[C@H]([C@H]4C[C@H]4c3nc2cc1F)c1ccccc1OCc1ccccc1 |r|
Structure:
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