Reaction Details Report a problem with these data
Target
Tumor necrosis factor
Ligand
BDBM403429
Substrate
n/a
Meas. Tech.
TNF or CD40L-Induced HEK-Blue Assay
IC50
17500±n/a nM
Citation
 Xiao, H; Dhar, TM; Jiang, B; Duan, J Cyclic compounds useful as modulators of TNF α US Patent  US10335392 Publication Date 7/2/2019 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM403429
Synonyms:
US10335392, Example 36
Type:
Small organic molecule
Emp. Form.:
C24H22N4O
Mol. Mass.:
382.4577
SMILES:
OCc1ccc(cn1)-c1ccc2nc3[C@@H]4CNC[C@@H]4[C@H](c4ccccc4)n3c2c1 |r|
Structure:
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