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Target
Tumor necrosis factor
Ligand
BDBM403430
Substrate
n/a
Meas. Tech.
TNF or CD40L-Induced HEK-Blue Assay
IC50
5500±n/a nM
Citation
 Xiao, H; Dhar, TM; Jiang, B; Duan, J Cyclic compounds useful as modulators of TNF α US Patent  US10335392 Publication Date 7/2/2019 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM403430
Synonyms:
US10335392, Example 37 | rac-(3aR,10S,10aS)—N-(tert-butyl)-7-(6-methoxypyridin-3-yl)-10-phenyl-3,3a,10,10a-tetrahydrobenzo[d]pyrrolo[3′,4′:3,4]pyrrolo[1,2-a]imidazole-2(1H)-carboxamide
Type:
Small organic molecule
Emp. Form.:
C29H31N5O2
Mol. Mass.:
481.5887
SMILES:
CC(C)(C)NC(=O)N1C[C@H]2[C@@H](C1)c1nc3ccc(cc3n1[C@H]2c1ccccc1)-c1ccc(CO)nc1 |r|
Structure:
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