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Target
Prokineticin receptor 1
Ligand
BDBM349647
Substrate
n/a
Meas. Tech.
BIOLOGICAL ASSAY
IC50
1880±n/a nM
Citation
 Mitchell, P; Teall, M Sulfonyl piperidine derivatives and their use for treating prokineticin mediated gastrointestinal disorders US Patent  US10335402 Publication Date 7/2/2019 
Target
Name:
Prokineticin receptor 1
Synonyms:
G-protein coupled receptor 73 | G-protein coupled receptor ZAQ | GPR73 | GPR73a | PK-R1 | PKR1 | PKR1_HUMAN | PROKR1
Type:
enzyme
Mol. Mass.:
44779.92
Organism:
Homo sapiens (Human)
Description:
Q8TCW9
Residue:
393
Sequence:
METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
  
Inhibitor
Name:
BDBM349647
Synonyms:
4-((3-Chloro-4-fluorophenyl)fluoromethylene)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl) piperidine | US10208016, Compound of Example 17 | US10335402, Example 17
Type:
Small organic molecule
Emp. Form.:
C17H18ClF2N3O2S
Mol. Mass.:
401.859
SMILES:
Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)=C(F)c1ccc(F)c(Cl)c1 |(-5.11,1.2,;-5.88,-.13,;-7.34,-.61,;-7.34,-2.15,;-5.88,-2.62,;-5.11,-3.96,;-4.98,-1.38,;-3.44,-1.38,;-3.44,.16,;-3.44,-2.92,;-1.9,-1.38,;-1.13,-.04,;.41,-.04,;1.18,-1.38,;.41,-2.71,;-1.13,-2.71,;2.72,-1.38,;3.49,-2.71,;3.49,-.04,;2.72,1.29,;3.49,2.62,;5.03,2.62,;5.8,3.96,;5.8,1.29,;7.34,1.29,;5.03,-.04,)|
Structure:
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