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Target
cAMP-dependent protein kinase catalytic subunit alpha
Ligand
BDBM37880
Substrate
n/a
Meas. Tech.
Dose-response biochemical assay for inhibitors of protein kinase A (PKA) activity
IC50
17860±n/a nM
Citation
 PubChem, PC Dose-response biochemical assay for inhibitors of protein kinase A (PKA) activity PubChem Bioassay (2007)[AID] 
Target
Name:
cAMP-dependent protein kinase catalytic subunit alpha
Synonyms:
KAPCA_HUMAN | PKA C-alpha | PKACA | PRKACA | cAMP-dependent protein kinase (PKA) | cAMP-dependent protein kinase catalytic (PKA) | cAMP-dependent protein kinase catalytic subunit alpha | cAMP-dependent protein kinase catalytic subunit alpha (PKA) | cAMP-dependent protein kinase catalytic subunit alpha (PKACA) | cAMP-dependent protein kinase catalytic subunit alpha (PKAc) | cAMP-dependent protein kinase catalytic subunit alpha isoform 1 | cAMP-dependent protein kinase, alpha-catalytic subunit
Type:
Enzyme Catalytic Subunit
Mol. Mass.:
40598.73
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
351
Sequence:
MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
  
Inhibitor
Name:
BDBM37880
Synonyms:
3-(2-furanylmethyl)-8-methoxy-5H-pyrimido[5,4-b]indol-4-one | 3-(2-furfuryl)-8-methoxy-5H-pyrimid[5,4-b]indol-4-one | 3-(furan-2-ylmethyl)-8-methoxy-5H-pyrimido[5,4-b]indol-4-one | MLS000078427 | SMR000039440 | cid_658506
Type:
Small organic molecule
Emp. Form.:
C16H13N3O3
Mol. Mass.:
295.2927
SMILES:
COc1ccc2[nH]c3c(ncn(Cc4ccco4)c3=O)c2c1
Structure:
Search PDB for entries with ligand similarity: