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Target
cAMP-dependent protein kinase catalytic subunit alpha
Ligand
BDBM37908
Substrate
n/a
Meas. Tech.
Dose-response biochemical assay for inhibitors of protein kinase A (PKA) activity
IC50
8899±n/a nM
Citation
 PubChem, PC Dose-response biochemical assay for inhibitors of protein kinase A (PKA) activity PubChem Bioassay (2007)[AID] 
Target
Name:
cAMP-dependent protein kinase catalytic subunit alpha
Synonyms:
KAPCA_HUMAN | PKA C-alpha | PKACA | PRKACA | cAMP-dependent protein kinase (PKA) | cAMP-dependent protein kinase catalytic (PKA) | cAMP-dependent protein kinase catalytic subunit alpha | cAMP-dependent protein kinase catalytic subunit alpha (PKA) | cAMP-dependent protein kinase catalytic subunit alpha (PKACA) | cAMP-dependent protein kinase catalytic subunit alpha (PKAc) | cAMP-dependent protein kinase catalytic subunit alpha isoform 1 | cAMP-dependent protein kinase, alpha-catalytic subunit
Type:
Enzyme Catalytic Subunit
Mol. Mass.:
40598.73
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
351
Sequence:
MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
  
Inhibitor
Name:
BDBM37908
Synonyms:
MLS000086548 | N-[4-(difluoromethylsulfanyl)phenyl]-7H-purin-6-amine | N-[4-(difluoromethylthio)phenyl]-7H-purin-6-amine | N-[4-[bis(fluoranyl)methylsulfanyl]phenyl]-7H-purin-6-amine | SMR000015967 | [4-(difluoromethylthio)phenyl]-(7H-purin-6-yl)amine | cid_692133
Type:
Small organic molecule
Emp. Form.:
C12H9F2N5S
Mol. Mass.:
293.295
SMILES:
FC(F)Sc1ccc(Nc2ncnc3nc[nH]c23)cc1
Structure:
Search PDB for entries with ligand similarity: