Reaction Details Report a problem with these data
Target
Macrophage migration inhibitory factor
Ligand
BDBM403753
Substrate
n/a
Meas. Tech.
Inhibition of Tautomerase Activity of Human MIF
Ki
8900±n/a nM
Citation
 Jorgensen, WL; Dziedzic, P; Cisneros, J Biaryltriazole inhibitors of macrophage migration inhibitory factor US Patent  US10336721 Publication Date 7/2/2019 
Target
Name:
Macrophage migration inhibitory factor
Synonyms:
GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase
Type:
Enzyme
Mol. Mass.:
12478.18
Organism:
Homo sapiens (Human)
Description:
P14174
Residue:
115
Sequence:
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
  
Inhibitor
Name:
BDBM403753
Synonyms:
US10336721, Example 3 | US10968198, Example 3
Type:
Small organic molecule
Emp. Form.:
C20H17FN4O2
Mol. Mass.:
364.373
SMILES:
COCCOc1ccc2nc(ccc2c1)-c1cn(nn1)-c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: