Reaction Details Report a problem with these data
Target
Macrophage migration inhibitory factor
Ligand
BDBM403765
Substrate
n/a
Meas. Tech.
Inhibition of Tautomerase Activity of Human MIF
Ki
29600±n/a nM
Citation
 Jorgensen, WL; Dziedzic, P; Cisneros, J Biaryltriazole inhibitors of macrophage migration inhibitory factor US Patent  US10336721 Publication Date 7/2/2019 
Target
Name:
Macrophage migration inhibitory factor
Synonyms:
GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase
Type:
Enzyme
Mol. Mass.:
12478.18
Organism:
Homo sapiens (Human)
Description:
P14174
Residue:
115
Sequence:
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
  
Inhibitor
Name:
BDBM403765
Synonyms:
US10336721, Example 23 | US10968198, Example 23
Type:
Small organic molecule
Emp. Form.:
C25H26FN5O3
Mol. Mass.:
463.504
SMILES:
Fc1ccc(cc1)-n1cc(nn1)-c1ccc2cc(OCCOCCN3CCOCC3)ccc2n1
Structure:
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