Target
Macrophage migration inhibitory factor
Ligand
BDBM50186426
Substrate
n/a
Meas. Tech.
Inhibition of Tautomerase Activity of Human MIF
Ki
21000±n/a nM
Citation
 Jorgensen, WLDziedzic, PCisneros, J Biaryltriazole inhibitors of macrophage migration inhibitory factor US Patent  US10336721 Publication Date 7/2/2019 
Target
Name:
Macrophage migration inhibitory factor
Synonyms:
GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase
Type:
Enzyme
Mol. Mass.:
12478.18
Organism:
Homo sapiens (Human)
Description:
P14174
Residue:
115
Sequence:
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
  
Inhibitor
Name:
BDBM50186426
Synonyms:
CHEMBL210858 | US10336721, ISO-1 | US10968198, ISO-1 | US8618147, ISO-1 | methyl 2-(3-(4-hydroxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate
Type:
Small organic molecule
Emp. Form.:
C12H13NO4
Mol. Mass.:
235.2359
SMILES:
COC(=O)CC1CC(=NO1)c1ccc(O)cc1 |c:7|
Structure:
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