Reaction Details Report a problem with these data
Target
Diphosphomevalonate decarboxylase
Ligand
BDBM38271
Substrate
n/a
Meas. Tech.
Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - DPM-DC Dose Response
IC50
15002±n/a nM
Citation
 PubChem, PC Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - DPM-DC Dose Response PubChem Bioassay (2007)[AID] 
Target
Name:
Diphosphomevalonate decarboxylase
Synonyms:
n/a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35571.44
Organism:
Streptococcus pneumoniae D39
Description:
A0A0H2ZN59
Residue:
317
Sequence:
MDREPVTVRSYANIAIIKYWGKKKEKEMVPATSSISLTLENMYTETTLSPLPANVTADEFYINGQLQNEVEHAKMSKIIDRYRPAGEGFVRIDTQNNMPTAAGLSSSSSGLSALVKACNAYFKLGLDRSQLAQEAKFASGSSSRSFYGPLGAWDKDSGEIYPVETDLKLAMIMLVLEDKKKPISSRDGMKLCVETSTTFDDWVRQSEKDYQDMLIYLKENDFAKIGELTEKNALAMHATTKTASPAFSYLTDASYEAMDFVRQLREKGEACYFTMDAGPNVKVFCQEKDLEHLSEIFGQRYRLIVSKTKDLSQDDCC
  
Inhibitor
Name:
BDBM38271
Synonyms:
3-Cyclohexyl-1-(7-oxo-2,3,6,7-tetrahydro-[1,4]dioxino[2,3-g]quinolin-8-ylmethyl)-1-(2-pyrrolidin-1-yl-ethyl)-urea | 3-cyclohexyl-1-[(7-keto-3,6-dihydro-2H-[1,4]dioxino[2,3-g]quinolin-8-yl)methyl]-1-(2-pyrrolidinoethyl)urea | 3-cyclohexyl-1-[(7-oxidanylidene-3,6-dihydro-2H-[1,4]dioxino[2,3-g]quinolin-8-yl)methyl]-1-(2-pyrrolidin-1-ylethyl)urea | 3-cyclohexyl-1-[(7-oxo-3,6-dihydro-2H-[1,4]dioxino[2,3-g]quinolin-8-yl)methyl]-1-(2-pyrrolidin-1-ylethyl)urea | 3-cyclohexyl-1-[(7-oxo-3,6-dihydro-2H-[1,4]dioxino[2,3-g]quinolin-8-yl)methyl]-1-[2-(1-pyrrolidinyl)ethyl]urea | MLS000030044 | SMR000004159 | cid_648925
Type:
Small organic molecule
Emp. Form.:
C25H34N4O4
Mol. Mass.:
454.5619
SMILES:
O=C(NC1CCCCC1)N(CCN1CCCC1)Cc1cc2cc3OCCOc3cc2[nH]c1=O
Structure:
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