Reaction Details Report a problem with these data
Target
Diphosphomevalonate decarboxylase
Ligand
BDBM38403
Substrate
n/a
Meas. Tech.
Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - DPM-DC Dose Response
IC50
15137.1±n/a nM
Citation
 PubChem, PC Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - DPM-DC Dose Response PubChem Bioassay (2007)[AID] 
Target
Name:
Diphosphomevalonate decarboxylase
Synonyms:
n/a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35571.44
Organism:
Streptococcus pneumoniae D39
Description:
A0A0H2ZN59
Residue:
317
Sequence:
MDREPVTVRSYANIAIIKYWGKKKEKEMVPATSSISLTLENMYTETTLSPLPANVTADEFYINGQLQNEVEHAKMSKIIDRYRPAGEGFVRIDTQNNMPTAAGLSSSSSGLSALVKACNAYFKLGLDRSQLAQEAKFASGSSSRSFYGPLGAWDKDSGEIYPVETDLKLAMIMLVLEDKKKPISSRDGMKLCVETSTTFDDWVRQSEKDYQDMLIYLKENDFAKIGELTEKNALAMHATTKTASPAFSYLTDASYEAMDFVRQLREKGEACYFTMDAGPNVKVFCQEKDLEHLSEIFGQRYRLIVSKTKDLSQDDCC
  
Inhibitor
Name:
BDBM38403
Synonyms:
3-(3-chloranyl-4-methoxy-phenyl)-N-(furan-2-ylmethyl)-5-methyl-4-oxidanylidene-pyridazino[4,5-b]indole-1-carboxamide | 3-(3-chloro-4-methoxy-phenyl)-N-(2-furfuryl)-4-keto-5-methyl-pyridazin[4,5-b]indole-1-carboxamide | 3-(3-chloro-4-methoxyphenyl)-N-(2-furanylmethyl)-5-methyl-4-oxo-1-pyridazino[4,5-b]indolecarboxamide | 3-(3-chloro-4-methoxyphenyl)-N-(2-furylmethyl)-5-methyl-4-oxo-4,5-dihydro-3H-pyridazino[4,5-b]indole-1-carboxamide | 3-(3-chloro-4-methoxyphenyl)-N-(furan-2-ylmethyl)-5-methyl-4-oxopyridazino[4,5-b]indole-1-carboxamide | MLS000045513 | SMR000027270 | cid_3238809
Type:
Small organic molecule
Emp. Form.:
C24H19ClN4O4
Mol. Mass.:
462.885
SMILES:
COc1ccc(cc1Cl)-n1nc(C(=O)NCc2ccco2)c2c3ccccc3n(C)c2c1=O
Structure:
Search PDB for entries with ligand similarity: