Reaction Details Report a problem with these data
Target
Diphosphomevalonate decarboxylase
Ligand
BDBM38410
Substrate
n/a
Meas. Tech.
Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - DPM-DC Dose Response
IC50
21619.5±n/a nM
Citation
 PubChem, PC Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - DPM-DC Dose Response PubChem Bioassay (2007)[AID] 
Target
Name:
Diphosphomevalonate decarboxylase
Synonyms:
n/a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35571.44
Organism:
Streptococcus pneumoniae D39
Description:
A0A0H2ZN59
Residue:
317
Sequence:
MDREPVTVRSYANIAIIKYWGKKKEKEMVPATSSISLTLENMYTETTLSPLPANVTADEFYINGQLQNEVEHAKMSKIIDRYRPAGEGFVRIDTQNNMPTAAGLSSSSSGLSALVKACNAYFKLGLDRSQLAQEAKFASGSSSRSFYGPLGAWDKDSGEIYPVETDLKLAMIMLVLEDKKKPISSRDGMKLCVETSTTFDDWVRQSEKDYQDMLIYLKENDFAKIGELTEKNALAMHATTKTASPAFSYLTDASYEAMDFVRQLREKGEACYFTMDAGPNVKVFCQEKDLEHLSEIFGQRYRLIVSKTKDLSQDDCC
  
Inhibitor
Name:
BDBM38410
Synonyms:
2-(2-methoxyphenyl)-9-(3-methylphenyl)-8-oxidanylidene-7H-purine-6-carboxamide | 2-(2-methoxyphenyl)-9-(3-methylphenyl)-8-oxo-7H-purine-6-carboxamide | 2-(2-methoxyphenyl)-9-(3-methylphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide | 8-keto-2-(2-methoxyphenyl)-9-(m-tolyl)-7H-purine-6-carboxamide | MLS000094139 | SMR000029751 | cid_3239826
Type:
Small organic molecule
Emp. Form.:
C20H17N5O3
Mol. Mass.:
375.3807
SMILES:
COc1ccccc1-c1nc(C(N)=O)c2[nH]c(=O)n(-c3cccc(C)c3)c2n1
Structure:
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