Reaction Details Report a problem with these data
Target
Diphosphomevalonate decarboxylase
Ligand
BDBM38427
Substrate
n/a
Meas. Tech.
Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - DPM-DC Dose Response
IC50
15192.3±n/a nM
Citation
 PubChem, PC Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - DPM-DC Dose Response PubChem Bioassay (2007)[AID] 
Target
Name:
Diphosphomevalonate decarboxylase
Synonyms:
n/a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35571.44
Organism:
Streptococcus pneumoniae D39
Description:
A0A0H2ZN59
Residue:
317
Sequence:
MDREPVTVRSYANIAIIKYWGKKKEKEMVPATSSISLTLENMYTETTLSPLPANVTADEFYINGQLQNEVEHAKMSKIIDRYRPAGEGFVRIDTQNNMPTAAGLSSSSSGLSALVKACNAYFKLGLDRSQLAQEAKFASGSSSRSFYGPLGAWDKDSGEIYPVETDLKLAMIMLVLEDKKKPISSRDGMKLCVETSTTFDDWVRQSEKDYQDMLIYLKENDFAKIGELTEKNALAMHATTKTASPAFSYLTDASYEAMDFVRQLREKGEACYFTMDAGPNVKVFCQEKDLEHLSEIFGQRYRLIVSKTKDLSQDDCC
  
Inhibitor
Name:
BDBM38427
Synonyms:
2-isonicotinoylimino-1-isopropyl-5-keto-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxylic acid ethyl ester | 5-oxo-2-[oxo(pyridin-4-yl)methyl]imino-1-propan-2-yl-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxylic acid ethyl ester | MLS000044283 | SMR000022065 | cid_2155914 | ethyl (2E)-2-(isonicotinoylimino)-1-isopropyl-5-oxo-1,5-dihydro-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxylate | ethyl 5-oxidanylidene-1-propan-2-yl-2-pyridin-4-ylcarbonylimino-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxylate | ethyl 5-oxo-1-propan-2-yl-2-(pyridine-4-carbonylimino)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C23H21N5O4
Mol. Mass.:
431.4439
SMILES:
CCOC(=O)c1cc2c(nc3ccccn3c2=O)n(C(C)C)\c1=N/C(=O)c1ccncc1
Structure:
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