Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 6
Ligand
BDBM35389
Substrate
n/a
Meas. Tech.
In vitro MKP-3 Phosphatase Dose Response Hit/Probe Assessment Assay
IC50
>50000±n/a nM
Citation
 PubChem, PC In vitro MKP-3 Phosphatase Dose Response Hit/Probe Assessment Assay PubChem Bioassay (2007)[AID] 
Target
Name:
Dual specificity protein phosphatase 6
Synonyms:
DUS6_RAT | Dusp6 | MAP kinase phosphatase 3 | MKP-3 | Mitogen-activated protein kinase phosphatase 3 | Mkp3
Type:
Enzyme
Mol. Mass.:
42303.19
Organism:
Rattus norvegicus
Description:
gi_16758752
Residue:
381
Sequence:
MIDTLRPVPFASEMAISKTVAWLNEQLELGNEQLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRCEDRDRFTRRCGTDTVVLYDENSSDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFALHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQQLYFTAPSNQNVYQVDSLQST
  
Inhibitor
Name:
BDBM35389
Synonyms:
MLS000046685 | N-cyclopropyl-4-keto-6-[[3-(trifluoromethyl)phenyl]sulfamoyl]-1H-quinoline-3-carboxamide | N-cyclopropyl-4-oxidanylidene-6-[[3-(trifluoromethyl)phenyl]sulfamoyl]-1H-quinoline-3-carboxamide | N-cyclopropyl-4-oxo-6-({[3-(trifluoromethyl)phenyl]amino}sulfonyl)-1,4-dihydroquinoline-3-carboxamide | N-cyclopropyl-4-oxo-6-[[3-(trifluoromethyl)phenyl]sulfamoyl]-1H-quinoline-3-carboxamide | SMR000032696 | cid_3238129
Type:
Small organic molecule
Emp. Form.:
C20H16F3N3O4S
Mol. Mass.:
451.419
SMILES:
Oc1c(cnc2ccc(cc12)S(=O)(=O)Nc1cccc(c1)C(F)(F)F)C(=O)NC1CC1
Structure:
Search PDB for entries with ligand similarity: