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Target
Bcl-2-related protein A1
Ligand
BDBM39121
Substrate
n/a
Meas. Tech.
TR-FRET secondary assay for HTS discovery of chemical inhibitors of anti-apoptotic protein Bfl-1
IC50
73700±11400 nM
Citation
 PubChem, PC TR-FRET secondary assay for HTS discovery of chemical inhibitors of anti-apoptotic protein Bfl-1 PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
A1 | A1-A | B-cell leukemia/lymphoma 2 related protein A1a | B2LA1_MOUSE | Bcl2a1 | Bcl2a1a | Bfl-1 | Bfl1 | Hemopoietic-specific early response protein | Protein BFL-1
Type:
Apoptosis regulator protein
Mol. Mass.:
19909.74
Organism:
Mus musculus (Mouse)
Description:
gi_11024684
Residue:
172
Sequence:
MAESELMHIHSLAEHYLQYVLQVPAFESAPSQACRVLQRVAFSVQKEVEKNLKSYLDDFHVESIDTARIIFNQVMEKEFEDGIINWGRIVTIFAFGGVLLKKLPQEQIALDVCAYKQVSSFVAEFIMNNTGEWIRQNGGWEDGFIKKFEPKSGWLTFLQMTGQIWEMLFLLK
  
Inhibitor
Name:
BDBM39121
Synonyms:
3-(benzylamino)-4-chloro-1-(3,4-dichlorophenyl)-1H-pyrrole-2,5-dione | 3-(benzylamino)-4-chloro-1-(3,4-dichlorophenyl)-3-pyrroline-2,5-quinone | 3-(benzylamino)-4-chloro-1-(3,4-dichlorophenyl)pyrrole-2,5-dione | 3-chloranyl-1-(3,4-dichlorophenyl)-4-[(phenylmethyl)amino]pyrrole-2,5-dione | 3-chloro-1-(3,4-dichlorophenyl)-4-[(phenylmethyl)amino]pyrrole-2,5-dione | CHEMBL1271992 | MLS-0067125.0001 | cid_1180669
Type:
Small organic molecule
Emp. Form.:
C17H11Cl3N2O2
Mol. Mass.:
381.64
SMILES:
Oc1c(Cl)c(N=Cc2ccccc2)c(O)n1-c1ccc(Cl)c(Cl)c1 |w:5.4|
Structure:
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