Reaction Details Report a problem with these data
Target
Coagulation factor XI
Ligand
BDBM32661
Substrate
n/a
Meas. Tech.
Factor XIa Dose Response Confirmation
IC50
>50000±0 nM
Citation
 PubChem, PC Factor XIa Dose Response Confirmation PubChem Bioassay (2008)[AID] 
Target
Name:
Coagulation factor XI
Synonyms:
Coagulation factor XIa | Coagulation factor XIa heavy chain | Coagulation factor XIa light chain | F11 | FA11_HUMAN | FXI | Factor XIa | Factor XIa (fXIa) | PTA | Plasma thromboplastin antecedent
Type:
Enzyme
Mol. Mass.:
70130.58
Organism:
Homo sapiens (Human)
Description:
P03951
Residue:
625
Sequence:
MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQAV
  
Inhibitor
Name:
BDBM32661
Synonyms:
7-Hydroxy-isothiazolo[4,3-d]pyrimidine-3-carboxylic acid m-tolylamide | 7-keto-N-(m-tolyl)-4H-isothiazolo[4,3-d]pyrimidine-3-carboxamide | MLS000030201 | N-(3-methylphenyl)-7-oxidanylidene-4H-[1,2]thiazolo[4,3-d]pyrimidine-3-carboxamide | N-(3-methylphenyl)-7-oxo-4H-[1,2]thiazolo[4,3-d]pyrimidine-3-carboxamide | N-(3-methylphenyl)-7-oxo-4H-isothiazolo[4,3-d]pyrimidine-3-carboxamide | SMR000000702 | cid_648002
Type:
Small organic molecule
Emp. Form.:
C13H10N4O2S
Mol. Mass.:
286.309
SMILES:
Cc1cccc(NC(=O)c2snc3c2nc[nH]c3=O)c1
Structure:
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