Reaction Details Report a problem with these data
Target
Coagulation factor XI
Ligand
BDBM32684
Substrate
n/a
Meas. Tech.
Factor XIa Dose Response Confirmation
IC50
>50000±0 nM
Citation
 PubChem, PC Factor XIa Dose Response Confirmation PubChem Bioassay (2008)[AID] 
Target
Name:
Coagulation factor XI
Synonyms:
Coagulation factor XIa | Coagulation factor XIa heavy chain | Coagulation factor XIa light chain | F11 | FA11_HUMAN | FXI | Factor XIa | Factor XIa (fXIa) | PTA | Plasma thromboplastin antecedent
Type:
Enzyme
Mol. Mass.:
70130.58
Organism:
Homo sapiens (Human)
Description:
P03951
Residue:
625
Sequence:
MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQAV
  
Inhibitor
Name:
BDBM32684
Synonyms:
2,5-diethoxy-N,N-bis(phenylmethyl)-4-(1,2,3,4-tetrazol-1-yl)benzenesulfonamide | 2,5-diethoxy-N,N-bis(phenylmethyl)-4-(1-tetrazolyl)benzenesulfonamide | MLS000123189 | N,N-Dibenzyl-2,5-diethoxy-4-tetrazol-1-yl-benzenesulfonamide | N,N-dibenzyl-2,5-diethoxy-4-(tetrazol-1-yl)benzenesulfonamide | SMR000123807 | cid_1428872
Type:
Small organic molecule
Emp. Form.:
C25H27N5O4S
Mol. Mass.:
493.578
SMILES:
CCOc1cc(c(OCC)cc1-n1cnnn1)S(=O)(=O)N(Cc1ccccc1)Cc1ccccc1
Structure:
Search PDB for entries with ligand similarity: