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Target
Alkaline phosphatase, germ cell type
Ligand
BDBM39761
Substrate
n/a
Meas. Tech.
Luminescent assay for HTS discovery of chemical inhibitors of placental alkaline phosphatase
IC50
10100±1850 nM
Citation
 PubChem, PC Luminescent assay for HTS discovery of chemical inhibitors of placental alkaline phosphatase PubChem Bioassay (2007)[AID] 
Target
Name:
Alkaline phosphatase, germ cell type
Synonyms:
ALPG | ALPPL | ALPPL2 | Alkaline phosphatase placental-like | PPBN_HUMAN | placental-like alkaline phosphatase preproprotein
Type:
PROTEIN
Mol. Mass.:
57374.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_29964
Residue:
532
Sequence:
MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP
  
Inhibitor
Name:
BDBM39761
Synonyms:
(5Z)-1-methyl-5-[(5-piperidin-1-ylfuran-2-yl)methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione | (5Z)-1-methyl-5-[(5-piperidino-2-furyl)methylene]-2-thioxo-hexahydropyrimidine-4,6-quinone | (5Z)-1-methyl-5-[[5-(1-piperidinyl)-2-furanyl]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione | 1-Methyl-5-[1-(5-piperidin-1-yl-furan-2-yl)-meth-(Z)-ylidene]-2-thioxo-dihydro-pyrimidine-4,6-dione | MLS000556843 | SMR000147960 | cid_5421118
Type:
Small organic molecule
Emp. Form.:
C15H17N3O3S
Mol. Mass.:
319.379
SMILES:
CN1C(=S)NC(=O)\C(=C\c2ccc(o2)N2CCCCC2)C1=O
Structure:
Search PDB for entries with ligand similarity: