Reaction Details Report a problem with these data
Target
Steroidogenic factor 1
Ligand
BDBM39518
Substrate
n/a
Meas. Tech.
Counterscreen for activators of the Retinoic Acid Receptor-related orphan receptor A (RORA): A cell-based dose-response assay for inhibition of the Steroidogenic Factor 1 (SF-1)
EC50
21000±n/a nM
Citation
 PubChem, PC Counterscreen for activators of the Retinoic Acid Receptor-related orphan receptor A (RORA): A cell-based dose-response assay for inhibition of the Steroidogenic Factor 1 (SF-1) PubChem Bioassay (2007)[AID] 
Target
Name:
Steroidogenic factor 1
Synonyms:
AD4BP | Adrenal 4-binding protein | FTZF1 | Fushi tarazu factor homolog 1 | NR5A1 | Nuclear receptor subfamily 5 group A member 1 | SF-1 | SF1 | STF-1 | STF1_HUMAN | Steroid hormone receptor Ad4BP
Type:
Nuclear Hormone Receptor
Mol. Mass.:
51643.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
461
Sequence:
MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPPPPPPAPDYVLPPSLHGPEPKGLAAGPPAGPLGDFGAPALPMAVPGAHGPLAGYLYPAFPGRAIKSEYPEPYASPPQPGLPYGYPEPFSGGPNVPELILQLLQLEPDEDQVRARILGCLQEPTKSRPDQPAAFGLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNCWSELLVFDHIYRQVQHGKEGSILLVTGQEVELTTVATQAGSLLHSLVLRAQELVLQLLALQLDRQEFVCLKFIILFSLDLKFLNNHILVKDAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT
  
Inhibitor
Name:
BDBM39518
Synonyms:
2-furanyl-[4-(3-phenyl-7-isothiazolo[4,5-d]pyrimidinyl)-1-piperazinyl]methanone | 2-furyl-[4-(3-phenylisothiazolo[4,5-d]pyrimidin-7-yl)piperazino]methanone | Furan-2-yl-[4-(3-phenyl-isothiazolo[4,5-d]pyrimidin-7-yl)-piperazin-1-yl]-methanone | MLS000027935 | SMR000006420 | cid_646378 | furan-2-yl-[4-(3-phenyl-[1,2]thiazolo[4,5-d]pyrimidin-7-yl)piperazin-1-yl]methanone
Type:
Small organic molecule
Emp. Form.:
C20H17N5O2S
Mol. Mass.:
391.446
SMILES:
O=C(N1CCN(CC1)c1ncnc2c(nsc12)-c1ccccc1)c1ccco1
Structure:
Search PDB for entries with ligand similarity: