Reaction Details Report a problem with these data
Target
fMet-Leu-Phe receptor
Ligand
BDBM40452
Substrate
n/a
Meas. Tech.
Formylpeptide Receptor (FPR) Ligand Structure Activity Relationship (SAR) Analysis : Dose Response Assay
Ki
>44300±n/a nM
Citation
 PubChem, PC Formylpeptide Receptor (FPR) Ligand Structure Activity Relationship (SAR) Analysis : Dose Response Assay PubChem Bioassay (2007)[AID] 
Target
Name:
fMet-Leu-Phe receptor
Synonyms:
FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38456.14
Organism:
Homo sapiens (Human)
Description:
gi_4503779
Residue:
350
Sequence:
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
  
Inhibitor
Name:
BDBM40452
Synonyms:
3-(4-methoxyphenyl)-2-methyl-4-(3-methylpiperidin-1-yl)carbonyl-3,4-dihydroisoquinolin-1-one | 3-(4-methoxyphenyl)-2-methyl-4-(3-methylpiperidine-1-carbonyl)-3,4-dihydroisocarbostyril | 3-(4-methoxyphenyl)-2-methyl-4-(3-methylpiperidine-1-carbonyl)-3,4-dihydroisoquinolin-1-one | 3-(4-methoxyphenyl)-2-methyl-4-[(3-methyl-1-piperidinyl)-oxomethyl]-3,4-dihydroisoquinolin-1-one | UNM000003608701 | cid_4147889
Type:
Small organic molecule
Emp. Form.:
C24H28N2O3
Mol. Mass.:
392.4907
SMILES:
COc1ccc(cc1)C1C(C(=O)N2CCCC(C)C2)c2ccccc2C(=O)N1C
Structure:
Search PDB for entries with ligand similarity: