Reaction Details Report a problem with these data
Target
fMet-Leu-Phe receptor
Ligand
BDBM40405
Substrate
n/a
Meas. Tech.
Formylpeptide Receptor (FPR) Ligand Structure Activity Relationship (SAR) Analysis : Dose Response Assay
IC50
18900±n/a nM
Citation
 PubChem, PC Formylpeptide Receptor (FPR) Ligand Structure Activity Relationship (SAR) Analysis : Dose Response Assay PubChem Bioassay (2007)[AID] 
Target
Name:
fMet-Leu-Phe receptor
Synonyms:
FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38456.14
Organism:
Homo sapiens (Human)
Description:
gi_4503779
Residue:
350
Sequence:
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
  
Inhibitor
Name:
BDBM40405
Synonyms:
(4E)-1-(2-methoxyethyl)-5-(2-methoxyphenyl)-4-[oxidanyl(phenyl)methylidene]pyrrolidine-2,3-dione | (4E)-4-[hydroxy(phenyl)methylene]-1-(2-methoxyethyl)-5-(2-methoxyphenyl)pyrrolidine-2,3-quinone | (4E)-4-[hydroxy(phenyl)methylidene]-1-(2-methoxyethyl)-5-(2-methoxyphenyl)pyrrolidine-2,3-dione | UNM000003537101 | cid_5290611
Type:
Small organic molecule
Emp. Form.:
C21H21NO5
Mol. Mass.:
367.3951
SMILES:
COCCN1C(C(C(=O)c2ccccc2)C(=O)C1=O)c1ccccc1OC
Structure:
Search PDB for entries with ligand similarity: