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Target
Heat shock protein HSP 90-alpha
Ligand
BDBM32159
Substrate
n/a
Meas. Tech.
Cell-based secondary assay for identifying Hsp90 inhibitors that degrade Hsp90 client protein Her2
IC50
48248.5±n/a nM
Citation
 PubChem, PC Cell-based secondary assay for identifying Hsp90 inhibitors that degrade Hsp90 client protein Her2 PubChem Bioassay (2007)[AID] 
Target
Name:
Heat shock protein HSP 90-alpha
Synonyms:
HS90A_HUMAN | HSP 86 | HSP86 | HSP90A | HSP90AA1 | HSPC1 | HSPCA | Heat Shock Protein 90 (Hsp90) | Heat shock 86 kDa | Heat shock protein HSP 90 (HSP90) | Heat shock protein HSP 90-alpha (HSP90) | Heat shock protein HSP 90-alpha (HSP90A) | LAP-2 | LPS-associated protein 2 | Lipopolysaccharide-associated protein 2 | Renal carcinoma antigen NY-REN-38 | heat shock protein 90kDa alpha (cytosolic), class A member 1 isoform 2
Type:
Molecular Chaperone
Mol. Mass.:
84623.45
Organism:
Homo sapiens (Human)
Description:
P07900
Residue:
732
Sequence:
MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
  
Inhibitor
Name:
BDBM32159
Synonyms:
N-[3-[(2,5-dichlorophenyl)sulfonylamino]-2-(2-hydroxyphenyl)phenyl]carbamic acid tert-butyl ester | TG2-71-1 | cid_16667754 | tert-butyl N-[3-[(2,5-dichlorophenyl)sulfonylamino]-2-(2-hydroxyphenyl)phenyl]carbamate | tert-butyl N-[3-[[2,5-bis(chloranyl)phenyl]sulfonylamino]-2-(2-hydroxyphenyl)phenyl]carbamate
Type:
Small organic molecule
Emp. Form.:
C23H22Cl2N2O5S
Mol. Mass.:
509.402
SMILES:
CC(C)(C)OC(=O)Nc1cccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)c1-c1ccccc1O |(17.81,-4.39,;17.04,-3.05,;18.37,-2.28,;15.7,-3.82,;16.27,-1.72,;14.73,-1.72,;13.96,-3.05,;13.96,-.39,;12.42,-.39,;12.42,-1.93,;11.08,-2.7,;9.75,-1.93,;9.75,-.39,;8.41,.39,;7.08,-.39,;6.31,.95,;7.85,-1.72,;5.75,-1.16,;5.75,-2.7,;4.41,-3.47,;4.41,-5.01,;3.08,-2.7,;3.08,-1.16,;4.41,-.39,;4.41,1.16,;11.08,.39,;11.08,1.93,;9.75,2.7,;9.75,4.24,;11.08,5.01,;12.42,4.24,;12.42,2.7,;13.96,2.7,)|
Structure:
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