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Target
Heat shock 70 kDa protein 1A
Ligand
BDBM31714
Substrate
n/a
Meas. Tech.
TR-FRET secondary assay for HTS discovery of chemical inhibitors of Hsp70
IC50
>100000±0 nM
Citation
 PubChem, PC TR-FRET secondary assay for HTS discovery of chemical inhibitors of Hsp70 PubChem Bioassay (2008)[AID] 
Target
Name:
Heat shock 70 kDa protein 1A
Synonyms:
HSPA1A | Heat Shock 70kDa Protein 1 | V9GZ37_HUMAN | heat shock 70kDa protein 1A
Type:
ATP-binding protein
Mol. Mass.:
51937.99
Organism:
Homo sapiens (Human)
Description:
gi_123271505; GST-tagged ATPase domain
Residue:
476
Sequence:
MAKAAAIGIDLGTTYSCVGVFQHGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD
  
Inhibitor
Name:
BDBM31714
Synonyms:
2-Ethyl-2H-pyrazole-3-carboxylic acid (5-chloro-pyridin-2-yl)-amide | MLS000529524 | N-(5-chloranylpyridin-2-yl)-2-ethyl-pyrazole-3-carboxamide | N-(5-chloro-2-pyridinyl)-2-ethyl-3-pyrazolecarboxamide | N-(5-chloro-2-pyridyl)-2-ethyl-pyrazole-3-carboxamide | N-(5-chloropyridin-2-yl)-2-ethylpyrazole-3-carboxamide | SMR000121999 | cid_1084322
Type:
Small organic molecule
Emp. Form.:
C11H11ClN4O
Mol. Mass.:
250.684
SMILES:
CCn1nccc1C(=O)Nc1ccc(Cl)cn1
Structure:
Search PDB for entries with ligand similarity: