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Target
Cathepsin B
Ligand
BDBM35512
Substrate
n/a
Meas. Tech.
Cathepsin B dose-response confirmation
IC50
844.5±15.7 nM
Citation
 PubChem, PC Cathepsin B dose-response confirmation PubChem Bioassay (2008)[AID] 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM35512
Synonyms:
3-oxo-2-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzoxazin-2-yl acetate | MLS000045631 | SMR000027588 | [3-oxidanylidene-2-(trifluoromethyl)-4H-1,4-benzoxazin-2-yl] ethanoate | [3-oxo-2-(trifluoromethyl)-4H-1,4-benzoxazin-2-yl] acetate | acetic acid [3-keto-2-(trifluoromethyl)-4H-1,4-benzoxazin-2-yl] ester | acetic acid [3-oxo-2-(trifluoromethyl)-4H-1,4-benzoxazin-2-yl] ester | cid_3243025
Type:
Small organic molecule
Emp. Form.:
C11H8F3NO4
Mol. Mass.:
275.1807
SMILES:
CC(=O)OC1(Oc2ccccc2NC1=O)C(F)(F)F
Structure:
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