Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM35522
Substrate
n/a
Meas. Tech.
Cathepsin B dose-response confirmation
IC50
12947.1±365.5 nM
Citation
 PubChem, PC Cathepsin B dose-response confirmation PubChem Bioassay (2008)[AID] 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM35522
Synonyms:
2-spiro[5,6,7,8-tetrahydro-1H-[1,2,4]triazolo[5,1-b]quinazoline-9,1'-cyclohexane]amine | MLS000111227 | SMR000107153 | cid_5310676 | spiro[5,6,7,8-tetrahydro-1H-[1,2,4]triazolo[5,1-b]quinazoline-9,1'-cyclohexane]-2-amine | spiro[5,6,7,8-tetrahydro-1H-[1,2,4]triazolo[5,1-b]quinazoline-9,1'-cyclohexane]-2-ylamine
Type:
Small organic molecule
Emp. Form.:
C14H21N5
Mol. Mass.:
259.35
SMILES:
Nc1nc2N=C3CCCCC3C3(CCCCC3)n2n1 |t:4|
Structure:
Search PDB for entries with ligand similarity: