Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM41157
Substrate
n/a
Meas. Tech.
Cathepsin L dose-response confirmation
IC50
>50000±0 nM
Citation
 PubChem, PC Cathepsin L dose-response confirmation PubChem Bioassay (2008)[AID] 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM41157
Synonyms:
4-amino-3-(2,5-difluorophenyl)-2-sulfanylidene-5-thiazolecarboxylic acid ethyl ester | 4-amino-3-(2,5-difluorophenyl)-2-thioxo-4-thiazoline-5-carboxylic acid ethyl ester | MLS000095487 | SMR000031041 | cid_3239616 | ethyl 4-amino-3-(2,5-difluorophenyl)-2-sulfanylidene-1,3-thiazole-5-carboxylate | ethyl 4-amino-3-(2,5-difluorophenyl)-2-thioxo-2,3-dihydro-1,3-thiazole-5-carboxylate | ethyl 4-azanyl-3-[2,5-bis(fluoranyl)phenyl]-2-sulfanylidene-1,3-thiazole-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C12H10F2N2O2S2
Mol. Mass.:
316.347
SMILES:
CCOC(=O)c1sc(=S)n(c1N)-c1cc(F)ccc1F |(7.12,6.15,;7.74,4.74,;6.84,3.49,;7.47,2.09,;9,1.93,;6.56,.84,;5.02,.84,;4.54,-.62,;3.08,-1.1,;5.79,-1.53,;7.04,-.62,;8.5,-1.1,;5.79,-3.07,;7.12,-3.84,;7.12,-5.38,;8.46,-6.15,;5.79,-6.15,;4.46,-5.38,;4.46,-3.84,;3.12,-3.07,)|
Structure:
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