Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM41179
Substrate
n/a
Meas. Tech.
Cathepsin L dose-response confirmation
IC50
1662.38±428.257 nM
Citation
 PubChem, PC Cathepsin L dose-response confirmation PubChem Bioassay (2008)[AID] 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM41179
Synonyms:
MLS000119698 | N-[3-(3,4-dihydro-1H-isoquinolin-2-yl)propyl]-1-(5-pyrrol-1-yl-1,3,4-thiadiazol-2-yl)isonipecotamide | N-[3-(3,4-dihydro-1H-isoquinolin-2-yl)propyl]-1-(5-pyrrol-1-yl-1,3,4-thiadiazol-2-yl)piperidine-4-carboxamide | N-[3-(3,4-dihydro-1H-isoquinolin-2-yl)propyl]-1-[5-(1-pyrrolyl)-1,3,4-thiadiazol-2-yl]-4-piperidinecarboxamide | SMR000096619 | cid_5308248
Type:
Small organic molecule
Emp. Form.:
C24H30N6OS
Mol. Mass.:
450.6
SMILES:
O=C(NCCCN1CCc2ccccc2C1)C1CCN(CC1)c1nnc(s1)-n1cccc1
Structure:
Search PDB for entries with ligand similarity: