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Target
Serine/threonine-protein kinase PLK1
Ligand
BDBM41791
Substrate
n/a
Meas. Tech.
Concentration Response fluorescence polarization-based assay to confirm small molecule inhibitors identified in the Polo box domain (PBD) of Plk1 Primary HTS.
IC50
>50000±n/a nM
Citation
 PubChem, PC Concentration Response fluorescence polarization-based assay to confirm small molecule inhibitors identified in the Polo box domain (PBD) of Plk1 Primary HTS. PubChem Bioassay (2007)[AID] 
Target
Name:
Serine/threonine-protein kinase PLK1
Synonyms:
PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase
Type:
Serine/threonine-protein kinase
Mol. Mass.:
68277.16
Organism:
Homo sapiens (Human)
Description:
P53350
Residue:
603
Sequence:
MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
  
Inhibitor
Name:
BDBM41791
Synonyms:
2-[(3,5,7-trimethyladamantane-1-carbonyl)amino]acetic acid methyl ester | 2-[[oxo-(3,5,7-trimethyl-1-adamantyl)methyl]amino]acetic acid methyl ester | MLS000099463 | SMR000074065 | cid_2944994 | methyl 2-[(3,5,7-trimethyl-1-adamantyl)carbonylamino]ethanoate | methyl 2-[(3,5,7-trimethyladamantane-1-carbonyl)amino]acetate | methyl N-[(3,5,7-trimethyl-1-adamantyl)carbonyl]glycinate
Type:
Small organic molecule
Emp. Form.:
C17H27NO3
Mol. Mass.:
293.4012
SMILES:
COC(=O)CNC(=O)C12CC3(C)CC(C)(CC(C)(C3)C1)C2 |TLB:6:8:12:16.15.18,17:16:12:8.20.9,THB:6:8:15:10.12.18,19:8:12:16.15.18,9:10:15:8.19.20,9:8:15:10.12.18,11:10:15:8.19.20|
Structure:
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