Target
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Ligand
BDBM264720
Substrate
n/a
Meas. Tech.
P. aeruqinosa LpxC Inhibition Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
<0.001±n/a nM
Comments
extracted
Citation
 Fu, JJin, XKarur, SLaPointe, GLee, PSweeney, ZK Isoxazoline hydroxamic acid derivatives as LpxC inhibitors US Patent  US9718792 Publication Date 8/1/2017 
Target
Name:
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Synonyms:
LPXC_PSEAE | Protein envA | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) | UDP-3-O-acyl-GlcNAc deacetylase | UDP-3-O-acyl-GlcNAc deacetylase (LpxC) | envA | lpxC
Type:
Enzyme
Mol. Mass.:
33428.15
Organism:
Pseudomonas aeruginosa
Description:
P47205
Residue:
303
Sequence:
MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFCRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRPAAAV
  
Inhibitor
Name:
BDBM264720
Synonyms:
US9718792, 1-B
Type:
Small organic molecule
Emp. Form.:
C14H17BrN2O5S
Mol. Mass.:
405.264
SMILES:
CC(CC1CC(=NO1)c1ccc(Br)cc1)(C(=O)NO)S(C)(=O)=O |c:5|
Structure:
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