Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM32264
Substrate
n/a
Meas. Tech.
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2
EC50
19810±n/a nM
Citation
 PubChem, PC Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2 PubChem Bioassay (2008)[AID] 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM32264
Synonyms:
4-(1-azepanyl)-2-(2-pyridinyl)quinazoline | 4-(azepan-1-yl)-2-(2-pyridyl)quinazoline | 4-(azepan-1-yl)-2-pyridin-2-yl-quinazoline | 4-(azepan-1-yl)-2-pyridin-2-ylquinazoline | MLS000042263 | SMR000046752 | cid_665597
Type:
Small organic molecule
Emp. Form.:
C19H20N4
Mol. Mass.:
304.3889
SMILES:
C1CCCN(CC1)c1nc(nc2ccccc12)-c1ccccn1
Structure:
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