Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM33078
Substrate
n/a
Meas. Tech.
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2
EC50
4650±n/a nM
Citation
 PubChem, PC Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2 PubChem Bioassay (2008)[AID] 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM33078
Synonyms:
MLS000530834 | N-(tert-butyl)-2-(4-{[(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)amino]methyl}phenoxy)acetamide | N-tert-butyl-2-[4-[[(2-keto-1,3-dihydrobenzimidazol-5-yl)amino]methyl]phenoxy]acetamide | N-tert-butyl-2-[4-[[(2-oxidanylidene-1,3-dihydrobenzimidazol-5-yl)amino]methyl]phenoxy]ethanamide | N-tert-butyl-2-[4-[[(2-oxo-1,3-dihydrobenzimidazol-5-yl)amino]methyl]phenoxy]acetamide | SMR000135772 | cid_1017369
Type:
Small organic molecule
Emp. Form.:
C20H24N4O3
Mol. Mass.:
368.4296
SMILES:
CC(C)(C)NC(=O)COc1ccc(CNc2ccc3[nH]c(=O)[nH]c3c2)cc1
Structure:
Search PDB for entries with ligand similarity: