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Target
Apoptosis regulator Bcl-2
Ligand
BDBM33159
Substrate
n/a
Meas. Tech.
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2
EC50
19650±n/a nM
Citation
 PubChem, PC Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2 PubChem Bioassay (2008)[AID] 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM33159
Synonyms:
MLS000392833 | N-[3-[(1,1-diketothiolan-3-yl)amino]-1,4-diketo-2-naphthyl]benzamide | N-[3-[(1,1-dioxo-3-thiolanyl)amino]-1,4-dioxo-2-naphthalenyl]benzamide | N-[3-[(1,1-dioxothiolan-3-yl)amino]-1,4-dioxonaphthalen-2-yl]benzamide | N-[3-[[1,1-bis(oxidanylidene)thiolan-3-yl]amino]-1,4-bis(oxidanylidene)naphthalen-2-yl]benzamide | SMR000261720 | cid_4654931
Type:
Small organic molecule
Emp. Form.:
C21H18N2O5S
Mol. Mass.:
410.443
SMILES:
O=C(NC1=C(NC2CCS(=O)(=O)C2)C(=O)c2ccccc2C1=O)c1ccccc1 |c:3|
Structure:
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