Reaction Details Report a problem with these data
Target
Cell division control protein 42 homolog
Ligand
BDBM43206
Substrate
n/a
Meas. Tech.
Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant
EC50
4308±n/a nM
Citation
 PubChem, PC Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant PubChem Bioassay (2010)[AID] 
Target
Name:
Cell division control protein 42 homolog
Synonyms:
CDC42 | CDC42_HUMAN | Cell division control protein 42 homolog | G25K GTP-binding protein | cell division cycle 42 (GTP binding protein, 25kDa)
Type:
PROTEIN
Mol. Mass.:
21258.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_652970
Residue:
191
Sequence:
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL
  
Inhibitor
Name:
BDBM43206
Synonyms:
3-(2-thenylcarbamoyl)picolinic acid | 3-(thiophen-2-ylmethylcarbamoyl)pyridine-2-carboxylic acid | 3-[oxo-(thiophen-2-ylmethylamino)methyl]-2-pyridinecarboxylic acid | 3-{[(thien-2-ylmethyl)amino]carbonyl}pyridine-2-carboxylic acid | MLS000045793 | SMR000028190 | cid_3237026
Type:
Small organic molecule
Emp. Form.:
C12H10N2O3S
Mol. Mass.:
262.284
SMILES:
OC(=O)c1ncccc1C(=O)NCc1cccs1
Structure:
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