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Target
Ras-related C3 botulinum toxin substrate 1
Ligand
BDBM43247
Substrate
n/a
Meas. Tech.
Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac activated mutant
EC50
12880±n/a nM
Citation
 PubChem, PC Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac activated mutant PubChem Bioassay (2010)[AID] 
Target
Name:
Ras-related C3 botulinum toxin substrate 1
Synonyms:
RAC1_MOUSE | Rac1 | Rac1 protein
Type:
PROTEIN
Mol. Mass.:
21455.91
Organism:
Mus musculus
Description:
EBI_101485
Residue:
192
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL
  
Inhibitor
Name:
BDBM43247
Synonyms:
2-[(5-cyano-4-keto-6-phenyl-1H-pyrimidin-2-yl)thio]-N-(5-methylisoxazol-3-yl)acetamide | 2-[(5-cyano-4-oxidanylidene-6-phenyl-1H-pyrimidin-2-yl)sulfanyl]-N-(5-methyl-1,2-oxazol-3-yl)ethanamide | 2-[(5-cyano-4-oxo-6-phenyl-1H-pyrimidin-2-yl)sulfanyl]-N-(5-methyl-1,2-oxazol-3-yl)acetamide | 2-[(5-cyano-4-oxo-6-phenyl-1H-pyrimidin-2-yl)thio]-N-(5-methyl-3-isoxazolyl)acetamide | 2-[(5-cyano-6-oxo-4-phenyl-1,6-dihydro-2-pyrimidinyl)thio]-N-(5-methyl-3-isoxazolyl)acetamide | MLS000089197 | SMR000072926 | cid_1081542
Type:
Small organic molecule
Emp. Form.:
C17H13N5O3S
Mol. Mass.:
367.382
SMILES:
Cc1cc(NC(=O)CSc2nc(-c3ccccc3)c(C#N)c(=O)[nH]2)no1
Structure:
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