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Target
Ras-related C3 botulinum toxin substrate 1
Ligand
BDBM43216
Substrate
n/a
Meas. Tech.
Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac activated mutant
EC50
10600±n/a nM
Citation
 PubChem, PC Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac activated mutant PubChem Bioassay (2010)[AID] 
Target
Name:
Ras-related C3 botulinum toxin substrate 1
Synonyms:
RAC1_MOUSE | Rac1 | Rac1 protein
Type:
PROTEIN
Mol. Mass.:
21455.91
Organism:
Mus musculus
Description:
EBI_101485
Residue:
192
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL
  
Inhibitor
Name:
BDBM43216
Synonyms:
(5Z)-2-(3,4-dihydro-1H-isoquinolin-2-yl)-5-(4-ethoxybenzylidene)-2-thiazolin-4-one | (5Z)-2-(3,4-dihydro-1H-isoquinolin-2-yl)-5-[(4-ethoxyphenyl)methylidene]-1,3-thiazol-4-one | (5Z)-2-(3,4-dihydro-1H-isoquinolin-2-yl)-5-[(4-ethoxyphenyl)methylidene]-4-thiazolone | 2-(3,4-Dihydro-1H-isoquinolin-2-yl)-5-[1-(4-ethoxy-phenyl)-meth-(Z)-ylidene]-thiazol-4-one | MLS000590730 | SMR000219207 | cid_1876676
Type:
Small organic molecule
Emp. Form.:
C21H20N2O2S
Mol. Mass.:
364.461
SMILES:
CCOc1ccc(\C=C2/SC(=NC2=O)N2CCc3ccccc3C2)cc1 |c:10|
Structure:
Search PDB for entries with ligand similarity: