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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43361
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
12660±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43361
Synonyms:
1-[4-[3-(1-benzotriazolyl)-2-hydroxypropoxy]phenyl]ethanone | 1-[4-[3-(benzotriazol-1-yl)-2-hydroxy-propoxy]phenyl]ethanone | 1-[4-[3-(benzotriazol-1-yl)-2-hydroxypropoxy]phenyl]ethanone | 1-[4-[3-(benzotriazol-1-yl)-2-oxidanyl-propoxy]phenyl]ethanone | MLS000112794 | SMR000108703 | cid_2917526
Type:
Small organic molecule
Emp. Form.:
C17H17N3O3
Mol. Mass.:
311.3352
SMILES:
CC(=O)c1ccc(OCC(O)Cn2nnc3ccccc23)cc1
Structure:
Search PDB for entries with ligand similarity: