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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43371
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
16150±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43371
Synonyms:
4-[[2-[2-(dipropylamino)ethylamino]-3,4-diketo-cyclobuten-1-yl]amino]piperidine-1-carboxylic acid ethyl ester | 4-[[2-[2-(dipropylamino)ethylamino]-3,4-dioxo-1-cyclobutenyl]amino]-1-piperidinecarboxylic acid ethyl ester | MLS000522666 | SMR000127933 | cid_9550915 | ethyl 4-[[2-[2-(dipropylamino)ethylamino]-3,4-bis(oxidanylidene)cyclobuten-1-yl]amino]piperidine-1-carboxylate | ethyl 4-[[2-[2-(dipropylamino)ethylamino]-3,4-dioxocyclobuten-1-yl]amino]piperidine-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C20H34N4O4
Mol. Mass.:
394.5084
SMILES:
CCCN(CCC)CCNc1c(NC2CCN(CC2)C(=O)OCC)c(=O)c1=O
Structure:
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