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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43444
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
827220±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43444
Synonyms:
2-(5-methyl-1-tetrazolyl)acetic acid ethyl ester | 2-(5-methyltetrazol-1-yl)acetic acid ethyl ester | MLS000729098 | SMR000307376 | cid_1505264 | ethyl (5-methyl-1H-tetrazol-1-yl)acetate | ethyl 2-(5-methyl-1,2,3,4-tetrazol-1-yl)ethanoate | ethyl 2-(5-methyltetrazol-1-yl)acetate
Type:
Small organic molecule
Emp. Form.:
C6H10N4O2
Mol. Mass.:
170.1692
SMILES:
CCOC(=O)Cn1nnnc1C
Structure:
Search PDB for entries with ligand similarity: