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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43481
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
2240±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43481
Synonyms:
MLS000778251 | Morpholine-4-carbothioic acid [2-oxo-1,2-dihydro-indol-(3E)-ylidene]-hydrazide | N'-(2-ketoindol-3-yl)morpholine-4-carbothiohydrazide | N'-(2-oxidanylideneindol-3-yl)morpholine-4-carbothiohydrazide | N'-(2-oxo-3-indolyl)-4-morpholinecarbothiohydrazide | N'-(2-oxoindol-3-yl)morpholine-4-carbothiohydrazide | SMR000414928 | cid_5421094
Type:
Small organic molecule
Emp. Form.:
C13H14N4O2S
Mol. Mass.:
290.341
SMILES:
O=C1N=c2ccccc2=C1NNC(=S)N1CCOCC1 |c:9,t:2|
Structure:
Search PDB for entries with ligand similarity: