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Target
Signal transducer and activator of transcription 1-alpha/beta
Ligand
BDBM43621
Substrate
n/a
Meas. Tech.
Dose response counterscreen assay for STAT3 activators: cell-based high throughput assay to measure STAT1 activation
EC50
>55700±n/a nM
Citation
 PubChem, PC Dose response counterscreen assay for STAT3 activators: cell-based high throughput assay to measure STAT1 activation PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 1-alpha/beta
Synonyms:
STAT1 | STAT1_HUMAN | Signal transducer and activator of transcription 1-alpha/beta | Transcription Factor STAT1 | Transcription factor ISGF-3 components p91/p84 | signal transducer and activator of transcription 1 isoform alpha
Type:
Cytosolic Transcription Factor
Mol. Mass.:
87327.69
Organism:
Homo sapiens (Human)
Description:
Stat1 was expressed in sf9 cells from a baculovirus encoding the recombinant proteins. Stat1 dimer binds to DNA.
Residue:
750
Sequence:
MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
  
Inhibitor
Name:
BDBM43621
Synonyms:
2-[(5E)-3-acetyl-2-methyl-5-(6-oxo-1-cyclohexa-2,4-dienylidene)-1,3,4-oxadiazolidin-2-yl]-N-phenylacetamide | 2-[(5E)-3-acetyl-2-methyl-5-(6-oxocyclohexa-2,4-dien-1-ylidene)-1,3,4-oxadiazolidin-2-yl]-N-phenylacetamide | 2-[(5E)-3-acetyl-5-(6-ketocyclohexa-2,4-dien-1-ylidene)-2-methyl-1,3,4-oxadiazolidin-2-yl]-N-phenyl-acetamide | 2-[(5E)-3-ethanoyl-2-methyl-5-(6-oxidanylidenecyclohexa-2,4-dien-1-ylidene)-1,3,4-oxadiazolidin-2-yl]-N-phenyl-ethanamide | MLS000394782 | SMR000242889 | cid_11175636
Type:
Small organic molecule
Emp. Form.:
C19H19N3O4
Mol. Mass.:
353.3719
SMILES:
CC(=O)N1N=C(OC1(C)CC(=O)Nc1ccccc1)c1ccccc1O |c:4|
Structure:
Search PDB for entries with ligand similarity: