Reaction Details Report a problem with these data
Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM43794
Substrate
n/a
Meas. Tech.
SAR assay for compounds activating TNAP in the absence of phosphate acceptor performed in a luminescent assay
EC50
8630±n/a nM
Citation
 PubChem, PC SAR assay for compounds activating TNAP in the absence of phosphate acceptor performed in a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM43794
Synonyms:
MLS-0239623.0001 | N'-[1-(4-methylphenyl)-4-pyrazolo[3,4-d]pyrimidinyl]acetohydrazide | N'-[1-(4-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-yl]acetohydrazide | N'-[1-(4-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-yl]ethanehydrazide | N'-[1-(p-tolyl)pyrazolo[3,4-d]pyrimidin-4-yl]acetohydrazide | cid_4975892
Type:
Small organic molecule
Emp. Form.:
C14H14N6O
Mol. Mass.:
282.3006
SMILES:
CC(=O)NNc1ncnc2n(ncc12)-c1ccc(C)cc1
Structure:
Search PDB for entries with ligand similarity: